products

Patch Ready Cells are pre‐qualified aliquots of cryopreserved cells which can be used in patch clamp assays without prior cultivation. The set of cell lines expresses pharmaceutically relevant ion channels including the six cardiac channels of the CiPA panel. The ion channel cell lines have been...

instaCELL cytotoxicity assay kits have been designed to improve the reliability and reproducibility of routine toxicity testing. The assay kit includes aliquots of cryopreserved assay ready cells which have been qualified for the testing. The cells can be used like a reagent instantly after thawing...

Chemicals or other environmental noxes which damage the DNA or interfere with cell division, may impact the genomic integrity of cells. This can result in cell death and cancer. To screen chemicals for their genotoxic and mutagenic potential multiple types of assays have been developed. A cell‐based...

The monocyte activation test (MAT) is used to detect or quantify substances that activate human monocytes to release endogenous mediators such as pro-inflammatory cytokines like tumor necrosis factor alpha (TNFα) which play an important role in fever pathogenesis. The MAT assay detects the presence...

Allergic contact dermatitis is an environmental health issue induced by chemicals. A set of alternative methods has been approved by the OECD to test potential skin sensitizers in vitro. The cell‐based assays represent early key events of the skin sensitization process. h‐CLAT, the human Cell Line...

The instaCELL TNF-α neutralization assay kit is used to determine the potency of tumor necrosis factor-alpha (TNF‑α) neutralizing/inhibiting therapeutics. These recombinant antibodies and soluble proteins are used to regulate excessive inflammatory responses in the body. A dysregulation of TNF-a is...

Tumor necrosis factor alpha (TNF-α) is a multifunctional signaling substance involved in local and systemic inflammation. Its primary function is the regulation of various immune cells and is therefore mainly secreted by macrophages. TNF-α can induce fever, apoptotic cell death, cachexia, and...