products

A possible genotoxic effect should be discovered as early as possible in the development of a new drug to avoid unnecessary costs. The instaCELL® micronucleus assay kit, based on OECD guideline 487, is a simple and quick method to determine the genotoxic potential of a candidate substance. The...

The activation of the ARE/Nrf2 pathway in keratinocytes is one of the key events in the complex cascade of skin sensitization. For the evaluation of potential sensitizers reporter gene cell lines, such as KeratinoSens®, have been validated (OECD 442D), which express luciferase upon Nrf2 activation.

...

Medical devices and material which comes in contact with a patient must be tested for biocompatibility before a product can be released for the market. As part of this, the cytotoxicity of extracts prepared from the materials is addressed. Sensitive indicator cells like L-929 mouse fibroblasts are...

Recombinant cell lines that functionally express human ion channels are a valuable tool to screen for drugs targeting pain, stroke, or metabolic diseases but also to test candidates for negative side effects that induce proarrhythmia (CIPA panel). A set of six sodium and potassium channel cell lines...

Allergic contact dermatitis is an environmental health issue induced by chemicals which have been identified as skin sensitizers. Recently a set of alternative methods has been published by the OECD replacing the animal local lymph node assay. The cell based assays represent early key events of the...

Kidney epithelial cells from the proximal part of the tubulus are an essential tool to specifically assess nephrotoxicity in vitro. ciPTEC cells are conditionally immortalized proximal tubular epithelial cells developed by the Radbound University Nijmegen (NL). The activity of two kidney specific...