instaCELL® KeratinoSens® assay kit

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Assay Ready vs. Continious Culture

The activation of the ARE/Nrf2 pathway in keratinocytes is one of the key events in the complex cascade of skin sensitization. For the evaluation of potential sensitizers, reporter gene cell lines such as KeratinoSens® have been validated (OECD 442D), which express luciferase upon Nrf2 activation.

Assay Ready KeratinoSens® Cells were qualified for the test in comparison with KeratinoSens® cells from a continious culture. The reference skin sensitizer EGDMA did not reveal any altered sensitivity in terms of viability (blue) or Nrf2 activation (red).

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