A possible genotoxic effect should be discovered as early as possible in the development of a new drug to avoid unnecessary costs. The instaCELL® micronucleus assay kit, based on OECD guideline 487, is a simple and quick method to determine the genotoxic potential of a candidate substance. The formation of micronuclei during cell division, caused by double-strand breaks, crosslinking etc., is used as a measure for the genotoxic damage. The cells are treated with the test substance directly on a microscope slide (3-well chamber, Ibidi®) and can be mounted and stained in one step (Fluoroshield™, ImmunoBioScience corp.), which makes the preparation very easy and convenient.

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